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KMID : 0648420100150020077
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Journal of Korean Society of Pediatric Endocrinology
2010 Volume.15 No. 2 p.77 ~ p.84
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Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome
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Park Deok-Bae
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Abstract
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Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, represents a spectrum of disease including steatohepatitis, fibrosis, and irreversible cirrhosis. Although a "benign" condition, NAFLD is a risk factor eventually leading to fibrosis and to non-alcoholic steatohepatitis (NASH). A number of evidences support an association between NAFLD/NASH and metabolic syndrome. The pathogenesis of NAFLD/NASH and metabolic syndrome seems to have common pathophysiological mechanisms, with focus on insulin resistance as a key factor. This review discusses the new aspects of NAFLD/NASH pathogenesis, and anticipate that such knowledge will eventually serve to the deveolpment of novel treatment strategies for this disease.
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KEYWORD
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Fatty liver, Metabolic syndrome X, Insulin resistance
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